منابع مشابه
Studies of thiamine deficient rat brains with in vivo and in vitro proton NMR spectroscopy
J t oduction T?I!amine, vitamin Bl, is essential for aerobic glucose metabolism. Thiamine deficiency (TD), a frequent complication of alcoholism caused by decreased thiamine absorption, may result in brain damage known as Wernicke’s encephalopathy. In chronic alcoholics, neurobehavioral deficits related to TD and brain glucose metabolism have been shown to recover during abstinence. However, th...
متن کاملSpatial localization in NMR spectroscopy in vivo.
Spatial localization techniques are necessary for in vivo NMR spectroscopy involving heterogeneous organisms. Localization by surface coil NMR detection alone is generally inadequate for deep-lying organs due to contaminating signals from intervening surface tissues. However, localization to preselected planar volumes can be accomplished using a single selective excitation pulse in the presence...
متن کاملLocalized proton NMR spectroscopy using stimulated echoes: applications to human skeletal muscle in vivo.
Localized proton NMR spectroscopy using stimulated echoes (STEAM) has been used to study metabolites in different proximal skeletal muscles of normal volunteers at rest. Single scan water-suppressed proton NMR spectra obtained at 1.5 and 2.0 T (Siemens Magnetom) from a 64-ml volume-of-interest (VOI) yield resonances due to triglycerides, phosphocreatine plus a minor contribution from creatine, ...
متن کاملLocalized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo.
Water-suppressed localized proton NMR spectroscopy using stimulated echoes has been successfully applied to detect metabolites in the human brain in vivo. The STEAM spectroscopy sequence allows single-step localization by exciting three intersecting slices. Water suppression is achieved by preceding chemical-shift-selective (CHESS) rf pulses. High-resolution (0.05 ppm) proton NMR spectra of hea...
متن کاملIn vivo assessment of focal brain lactate alterations with NMR proton spectroscopy.
Spectral editing techniques and localization of 1H signals were applied to monitor lactate accumulation in a circumscribed region of brain damage. The experiments were performed at 2.35 T (100 MHz) in a 40-cm bore magnet. Following unilateral craniectomy in anesthetized adult cats, a two-turn surface coil was positioned over the dural surface. Proton spectra were obtained before and 1-5 h after...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1984
ISSN: 0014-5793
DOI: 10.1016/0014-5793(84)81371-x